![]() Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy. The full-text minute index is often used to make alignment very fast. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. As the rate of sequencing increases, greater throughput is demanded from read aligners. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.ĪB - As the rate of sequencing increases, greater throughput is demanded from read aligners. Publication types Research Support, N.I.H., Extramural Research Support, Non-U.S. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy. N2 - As the rate of sequencing increases, greater throughput is demanded from read aligners. Bowtie2 indexes the genome with a Burrows-Wheeler index to keep its memory footprint small: typically about 2.2 GB for the human genome (2.9 GB for paired-end). It aligns short DNA sequences (reads) to the human genome at a rate of over 25 million 35-bp reads per hour. and an Amazon Web Services in Education Research grant to B.L. Bowtie2 is an ultrafast, memory-efficient short read aligner. This work was supported in part by US National Institutes of Health grants R01-HG006102 and R01-GM083873 to S.L.S. T1 - Fast gapped-read alignment with Bowtie 2
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